![]() ![]() For these patients, there was a confirmation of this similar response, with a little more than 80% of patients responding to selpercatinib with their CNS disease. Twenty-two additional patients had measurable CNS disease, with multiple different fusion partners. Of the 11 patients who had intracranial disease that was measurable, 91% responded, with one-third of them having a complete response and two-thirds a partial response, and the DOR intracranially was also significant, with a decent amount of 10.1 months. We also saw from this study that there was an intracranial response for patients who had measurable intracranial disease. This was a significant duration of disease control, and those responses were seen regardless of the type of prior treatment, as well as regardless of the RET fusion partner. Then I think what we are looking to more and more is the duration of response when people do respond, and the DOR was not reached in the treatment-naive cohort and was about 18 months in the prior platinum chemotherapy. The response in the prior treatment cohort was 64% to 70%, depending on which assessment, whereas in treatment-naive patients it was 85% to 90%. What was most impressive from this study were the response rates that we saw in both the patients who had platinum chemotherapy previously and the patients who were not previously treated. What was the efficacy of the LIBRETTO-001 trial? There were patients who had brain metastases in both cohorts, and the KIF5B- RET fusion was the most common. They had adenocarcinoma, and in the, they all had had platinum-based chemotherapy and some already had a multitargeted tyrosine kinase inhibitor. On the LIBRETTO-001 trial, the patients in both cohorts were similar in age, race, and ECOG status. 3 It was a large trial that had several cohorts, and we’ll briefly discuss the data from the RET fusion–positive metastatic NSCLC cohort, which had 2 cohorts within that cohort, 1 of which was treatment naive, and the second was patients who were previously treated with platinum chemotherapy. The LIBRETTO-001 trial was a phase 1/2 trial that used selpercatinib in patients with RET fusion–positive NSCLC. ![]() Which trials back the approval and recommendation of selpercatinib? What treatments are recommend for these patients?Ĭertainly, from the National Comprehensive Cancer Network guidelines and the FDA perspective, both selpercatinib and pralsetinib have been approved, and they’re both listed as preferred on the NCCN guidelines. We also know that there is a difference between mutation and fusion, and that fusions are the predominant mechanism in lung cancer, with the KIF5B being the most common fusion that we see, in about 70% to 90% of patients with lung cancer. Targeted Oncology TM: How often are RET mutations seen in patients with cancer?īAUMAN: RET fusions and mutations are associated with oncogenesis across multiple different malignances, the most common being papillary thyroid cancer, medullary thyroid cancer, and non–small cell lung cancer, though there have been RET alterations seen in other places. ![]() Review of these data were part of a discussion about a 59-year-old patient during a virtual Targeted Oncology Case-Based Roundtable event. ![]() Jessica Bauman, MD, the chief, Division of Head and Neck, Medical Oncology, assistant professor, Department of Hematology/Oncology, and associate program director, Hematology/Oncology Fellowship Training Program at Fox Chase Cancer Center, reviewed data from the LIBRETTO-001 and ARROW trials which show the efficacy and safety of selpercatinib (Retevmo) and pralsetinib (Gavreto) for the treatment of patients with RET fusion-positive lung cancer. ![]()
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![]() ![]() When you stand a few feet away you hear the sum of all of these sounds, but when you close mic, or use a pickup, you have to pick one aspect of the tone, and essentially throw the rest out. Every piece of the instrument is making a different tone. And in fact that's true for any primarily acoustic instrument, that can have pickups put on it (violin, cello, upright bass, piano etc). So for acoustic I would say always mic it. And even that one sounded better miced from the outside) (the only guitar I've worked with that got close enough was a Brazilian Rosewood Taylor 814e with the Fishman Electronics package. The higher end ones will include a microphone that adds enough tone that you could probably get away with it. The lower end ones simply have a magnetic pickup behind the string next to the sound hole, or a piezo pickup behind the bridge. It also has a lot to do with the guitar, and the electronics package. It will still sound too much like an acoustic to be very useful in electric guitar applications, but not have the tone to stand up in a recording. CONNECT YOUR GUITAR, UKULELE OR OTHER INSTRUMENT TO YOUR PHONE WITH iRIG ACOUSTIC AND PROCESS WITH 3 AMPLIFIERS. ![]() There is however a significant sacrifice in tone to make it happen. THE NUMBER ONE TONE STUDIO HAS GONE ACOUSTIC. The electric acoustic is mainly intended for acoustic guitar sound live performances, where it wouldn't be practical to mic the guitar. Of the pick on strummed chords in addition to the electric guitarĪs a general rule, for recording, you want to use the right instrument to get the exact sound you want. I even mic'ed my Strat at the pickups so that I'd get the sound IK Multimedia is the owner of award-winning mastering plugin T-Racks. To me, it's all just personal preference with IK Multimedia is known as one of the top VST plugins and instruments manufacturer. But on other songs I've done I wanted that soundīut also the high frequency stuff and 'clickiness' of the pick Going direct to me is warmer, fuller,Īnd has much less high frequency content. In my personal experience, it's really just a matter of personal Would you normally just expect to plug it straight in via an interface like the Cakewalk or would you normally amp it a bit first? Is it not possible to get an acceptable sound without one? sorry if that seems daft but I have no experience of anything other an electric guitar as I only do instrumental stuff and I use Superior Drummer, SampleTank etc. Thanks - I was hoping I wouldn't need a mike for an electro-acoustic. ![]() ![]() ![]() Which Microsoft Word features are imported? Import TOC Entries from Outline Select to When you select an older Word file and select Show Filter Preferences, you can choose from these settings: The options available for placing Word 6.0 and Word 7.0 (Word 95) text differ from those available for later versions. Setting filter preferences for Word 6–7 files Import Tables Select to import tables as tabdelimited text (that is, each row in the table becomes a separate paragraph consisting of the cell data separated by tabs). When this option is unselected, the As Page Break Before and As Column Break Before options are unavailable. Because of this, you may be unable to resize a text block in PageMaker by dragging its bottom windowshade handle (that is, the windowshade snaps back to its original position). Import Page Break Before Paragraph Do not select this option, or PageMaker will be unable to place paragraphs that have the Page Break Before attribute set in the Word document. You can select Page Break Before, Column Break Before, or No Break. Page Break Before Paragraph As Determines how page breaks from the word-processing file are formatted in PageMaker. Condensed/Expanded Spacing To Interprets condensed or expanded spacing as range tracking when you select Tracking, or as the set width of characters when you select Kerning. For example, if you select Table of Contents Text, the text in the table is imported as tab-delimited text if you select Footnotes/Endnotes, footnotes and endnotes are imported at the end of the story. Include Imports the following selected items as part of the text in the story: Table of Contents Text, Index Text, Import Table(s) Text, and Footnotes/Endnotes. The dialog box includes the following options: The options you select in the dialog box remain in effect until you change them or exit PageMaker. 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Show Filter Preferences or hold down Shift while you double-click the file.ģ If the Filter Preferences dialog box appears,
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